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OLIGONUCLEOTIDE & PEPTIDE WHITEPAPERS

We take the time to create these whitepapers to help educate our audience about a particular topic and promote a best practice methodology. Consider these advanced problem-solving guides!

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Whitepapers Available For Download

Drug Delivery of Oligonucleotides, peptides, RNA, mRNA and CRISPR: Challenges, Innovations, Strategies

Research and innovation in drug delivery systems is a rapidly evolving field, especially as the scope of drugs now  encompasses not only small molecule drugs but also biological macromolecules including DNA, RNA, proteins and peptides.

As a field that has seen fast paced expansion as far as research and development is concerned, it encounters many challenges in terms of development of delivery systems catering to these novel drug entities. The challenges are numerous-from the choice of the perfect delivery system and formulations that are specific for each of the macromolecular subtypes.

This whitepaper talks about the challenges, strategies and innovations when it comes to drug delivery of oligonucleotides, peptides, RNA, mRNA and CRISPR.

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CMC Approaches to Accelerate Peptide, Oligonucleotide and mRNA Therapeutics

One of the greatest challenges when is comes to drug approval is the Chemistry, Manufacturing, and Control (CMC) of quality processes.

Some of these challenges include determining critical quality attributes and critical process parameters, low transduction efficiency, assessment of potency, assurance of product sterility, process validation, stability, and production at multiple manufacturing sites.
 

This whitepaper that highlights CMC approaches to accelerate peptide, oligonucleotide and mRNA therapeutic development.

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The Future of Peptide Vaccines and Personalized Peptide Therapies

Synthetic peptide vaccines are a nascent but highly promising therapeutic class. The field unites cancer biology and infectious disease treatment principles. There is, however, a key difference, a cancer vaccine is not prophylactic. Even though infectious disease prophylactic vaccines, such as against HPV, can prevent cancer, personalized cancer vaccines are an active treatment of an existing tumor.

This whitepaper focuses on peptide cancer vaccines, although infectious disease vaccines are also touched upon. Several considerations are important such as the peptide selection, and strategies to overcome loss of MHC. Personalization opens up regulatory challenges and these are also discussed.

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