Surajit Sinha

. at Indian Association for the Cultiva of SC

Speaker

Prof. Sinha graduated from School of Chemical Sciences, I. I. Sc., Bengaluru where he worked on organic synthesis and natural product chemistry under Prof. S. Chandrasekaran. After his Ph.D, he did his 1^st post doctoral study on origin of life related to search for a pre-biotic route of DNA under Prof. Christopher Switzer at University of California, Riverside in NASA Astrobiology project. Dr. Sinha then moved to Stanford University, Chemical and Systems Biology department for 2^nd post doctoral research. His work was on small molecule modulation of Hedgehog Signaling Pathway and spatiotemporal regulation of genes in zebrafish models using photo-caged morpholino. At Stanford, he worked with Prof. James K. Chen. Dr. Sinha joined the Indian Association for the Cultivation of Science in 2006 and now became a senior Professor. He is working on natural product analog, a possible substitute of morphine and development of a non-peptidic delivery vehicle for the delivery of peptides and antisense oligonucleotides. His notable work is on the synthesis of morpholino oligonucleotides, piperidino moprholino, G-clamp morpholino and cell-permeable morpholino and their application in splice modulation and gene silencing activities. The importance of his work was discussed in several media and in the Parliament, New Delhi. He is associated with DMD forum in India. He has authored 75 publications with 3 US patents and three book chapters. He mentored 14 PhD students and several master project students and postdoctoral associates.