Informa Life Sciences is part of the Knowledge and Networking Division of Informa PLC

This site is operated by a business or businesses owned by Informa PLC and all copyright resides with them. Informa PLC's registered office is 5 Howick Place, London SW1P 1WG. Registered in England and Wales. Number 3099067.

Informa
Key Sessions

Andrew Parker

Glepaglutide, A Long-Acting GLP-2 Analog in Development for the Treatment of Short Bowel Syndrome

Zealand Pharma A/S

Daniel Obrecht

Discovery and Development of a New Class of Macrocyclic Peptide Antibiotics

Polyphor Ltd.

08:00 - 09:00 60 mins
Registration
09:00 - 09:10 10 mins
Chairperson’s Opening Remarks
09:10 - 09:45 35 mins
PEPTIDE DISCOVERY AND DRUG DEVELOPMENT STRATEGIES
Critical Industry Update on the Status and Future Visions for Peptide Therapeutics:
more

Next generation peptide therapeutics

  • What are the pipelines looking like today?
  • Where is the future heading?
  • What types of products are coming through development?
  • New modalities
  • Where are the new fields for peptides beyond metabolic diseases?
  • Updates in targeting undruggable spaces with peptides
  • Will peptides be able to replace antibody therapies for many indications?

Overview of the expansions of peptides in:

  • Peptide vaccine market
  • New therapeutic areas e.g. immunology
  • Intracellular peptides
  • Conjugated peptides – small molecule and biopharmaceutical conjugates
  • Using peptide drug discovery platforms in new ways
  • Peptides as accessory vehicles

Future opportunities for peptide therapeutics

09:45 - 10:20 35 mins
PEPTIDE DISCOVERY AND DRUG DEVELOPMENT STRATEGIES
Peptide Selection Technologies to Optimise Peptide Target Affinity and Protein Interaction
  • Jigar Patel - Director Next Gen Technologies, Roche Diagnostics
more
10:20 - 10:55 35 mins
PEPTIDE DISCOVERY AND DRUG DEVELOPMENT STRATEGIES
The Peptide Discovery Platform: Overview, Application in Projects and Future Directions
  • Lukas Leder - Investigator, Novartis Institutes for Biomedical Research (NIBR), Switzerland
more

The peptide discovery platform is based on an mRNA display technique that is able to identify a variety of high affinity binding peptides. They have typically macrocyclic scaffold and contain natural and non-natural amino acids. These peptides can support drug discovery projects in different manners and some examples will be shown. Further method developments and innovations to generate more impact of the platform will be also presented.

10:55 - 11:30 35 mins
Morning Coffee Break and Networking
11:30 - 12:05 35 mins
PEPTIDE DISCOVERY AND DRUG DEVELOPMENT STRATEGIES
In Cellulo Library-Derived Peptide Based Inhibitors: Towards A Treatment For Parkinson’s Disease
  • Jody Mason - Associate Professor in Biochemistry, University of Bath
more

Aggregation of the alpha-Synuclein (aS) protein inside dopamine producing cells leads to PD by forming toxic Lewy bodies that interfere with normal brain function. We are utilising vast peptide libraries to identify those that both bind but most importantly are able to effectively block aS associated toxicity. Novelty lies in the fact that peptide selection is undertaken entirely inside living cells, with no assumptions made regarding mechanism of binding. Further novelty lies in the 45-54 region of aS which serves as a template for our library designs. This region is frequently mutated in early onset PD and is key to the pathogenic structure recently identified from CryoEM studies. Intracellular library screening and selection removes promiscuous peptides that bind to other proteins, as well as those that are unstable, insoluble, and degraded by enzymes. The most promising compounds have been characterised using a range of biophysical, structural, and cell-based experiments to i) increase understanding of how aggregation and toxicity are coupled, and ii) generate molecules for future use in PD diagnostics and prevention.

12:05 - 12:40 35 mins
PEPTIDE DISCOVERY AND DRUG DEVELOPMENT STRATEGIES
Multi-Parameter Optimisation of Exendin-4 based Polyagonists
  • Andreas Evers - Senior Scientist, Integrated Drug Discovery, Sanofi
more

In parallel to activity optimisation at the target receptor(s), we consider physical & chemical peptide properties as primary optimisation parameter. For this purpose, orthogonal experimental methods and different in silico approaches are continuously implemented and applied in an iterative manner for the optimisation of functional, physical & chemical peptide properties, considering requirements of the final drug product.

12:40 - 13:15 35 mins
PEPTIDE DISCOVERY AND DRUG DEVELOPMENT STRATEGIES
Glepaglutide, A Long-Acting GLP-2 Analog in Development for the Treatment of Short Bowel Syndrome
  • Andrew Parker - CSO & SVP, Head of Research & External Innovation, Zealand Pharma A/S
more

An overview of progression of glepaglutide from lead optimisation to Phase III clinical studies.

13:15 - 14:15 60 mins
Lunch and Networking
14:15 - 14:50 35 mins
PEPTIDE DISCOVERY AND DRUG DEVELOPMENT STRATEGIES
Discovery and Development of a New Class of Macrocyclic Peptide Antibiotics
  • Daniel Obrecht - Chief Scientific Officer, Co-Founder, Polyphor Ltd.
more

This presentation focuses on the discovery of the outer-membrane targeting antibiotic (OMPTA) class applying PEM technology [1]. OMPTAs target specifically Gram-negative bacteria by binding to lipopolysaccharide and outer-membrane proteins. Murepavadin (POL7080) is in phase III and the first member of this class [2]. The discovery and development up to preclinical stage of a novel class of OMPTA with medium-spectrum activity against all Gram-negative priority 1/ESKAPE pathogens overcoming also colistin resistant strains will be described.

14:50 - 15:25 35 mins
PEPTIDE DISCOVERY AND DRUG DEVELOPMENT STRATEGIES
New Modalities and Peptide Drug Development Strategies
  • Anna Maria Papini - Coordinator of the Interdepartmental French-Italian Laboratory of Peptide & Protein Chemistry & Biology, Università degli Studi di Firenze, Italy
more
15:25 - 16:00 35 mins
PEPTIDE DISCOVERY AND DRUG DEVELOPMENT STRATEGIES
Panel Discussion: Cost of Goods Modelling and Strategies to Evaluate Potential Drug Candidates
more
  • Evaluating potential drug candidates in early stage R&D
  • New leads: Calculating what these look like from a cost of goods perspective in later stage production
  • What is a good cost of goods model to apply for peptide therapeutics?
  • Upscaling of leads – How will potential leads scale up? Manufacturing considerations of complex peptide candidates
  • Environment impact on early phase design and R&D from the restricted use of solvents in large scale production
  • Translating from small batches for phase I or II to commercial scale? How to estimate costs for commercial production?



Panelists made up of a selection of speakers from the event

16:00 - 16:30 30 mins
End of Day One followed by Optional Evening Workshop
16:30 - 18:30 120 mins
Workshop: Novel Developments in the Cost-Efficient Production of Peptides

This evening workshop will focus on novel developments in the cost-efficient production of peptides. Through a series of presentations, the following areas will be addressed:


• CRO-CMO
• Enzymatic peptide synthesis
• Silica based purification
• Modelling