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Informa

25-26 November 2019
Radisson Blu Edwardian Grafton,
London

Upstream Bioprocess Development

Gain a clear overview of upstream process development for successful transfer to downstream processing on this 2-day course

Course Overview

Balancing the demands of product quality, process productivity and scalability remain the key challenges for professionals involved in upstream process development. This course will address these core issues for both mammalian and microbial products.

Starting with cell-line development, the course will move on to focus on media selection, screening, initial upstream process development and quality concerns to help you in laying the foundations for a success and productive process. On day two, you will explore upstream equipment in-depth and start to consider process characterisation, performance validation and scale up. You will also discuss the needs of the downstream process, how collaboration between USP and DSP teams can be facilitated and how process transfer can be addressed.

Taught by Margit Holzer, an experienced bioprocess development expert, this course will deliver a wealth of examples and discussion to help you in your learning.

What will you learn?

Cell-line development

Understand the intricacies of cell line development including sequencing, cloning, productivity and cell banking

Media selection

Consider selection of media for different production stages, testing and characterisation, viral and GMP concerns

Equipment

Discuss upstream equipment, the types available and its applications

Integration with DSP

Note how USP can be successfully integrated with downstream processing, how scale up can be managed and process transfer facilitated

Control strategy

Understand requirements for control strategy and process performance validation


Who is this course for?

This course will be of interest to professionals involved in upstream process development, including:

  • Process scientists
  • Technicians and technologists
  • Bioprocess engineers
  • Cell line development specialists
  • Cell culture specialists
  • Product managers
  • Process development managers
  • QA
  • Quality
  • Validation technicians
  • Managers

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