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In 1981, Dr. Sanghvi received his Ph.D. in organic chemistry from National Chemical Laboratory (Pune, India), where he worked on the synthesis of natural products. From 1982 – 1985, his post-doctoral research on the synthesis of modified nucleosides was carried out at University of London with Professor C.B. Reese. In 1986, he joined the Nucleic Acids Research Institute at ICN Pharmaceuticals, California. At ICN, he was involved in the design, synthesis and screening of novel nucleosides and nucleotides as antiviral and antitumor agents. From 1989 – 2003, he worked at Isis Pharmaceuticals, California. The main focus of his research at Isis has been on the discovery, development and manufacture of oligonucleotide based therapeutics, DNA and RNA modifications in combinatorial and diagnostic research.
Dr. Sanghvi have authored/co-authored over 160 scientific publications in leading journals, including several book chapters and have interventorship/co-inventorship of more than 40 patents. Throughout his professional history, he has attended and made numerous presentations at local and international scientific meetings and have successfully organized several symposiums. He is an editor of ACS book entitled Carbohydrate Modifications in Antisense Research published in 1994.
In May 2003, he founded Rasayan Inc., a company focused on the consulting, outsourcing services and supply of products related to nucleic acid field. Rasayan is engaged in the strategic planning, securing raw materials for manufacture of oligonucleotide-based drugs on large-scale, experimental design, optimization of synthesis and purification protocols on lab scale to kilo scale, including process chemistry. His specific interests include design, synthesis, chemistry and biochemistry of novel carbohydrates, nucleosides, nucleotides, and oligonucleotides for their application in therapeutics, combinatorial chemistry and medical diagnostic research.