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The Microbiome is one of the hottest areas of personalized medicine being studied. Experts in pharma, biotech, and investors are checking out how they can be a part of this emerging space – and what discoveries are next.
Clinical development and research in multiple therapeutic areas, including allergies, infant health, and microbiome discovery and application beyond the gut.
Learn what is being done to steer the relevance and future direction of the human microbiome frontier.
- Case study: Early life microbiome development, focusing on the part of the microbiome that concern fungi in pre-term children, and correlated fungal and bacterial composition to health risks such as NEC and sepsis.
- Explore key findings in the implication of pre-term birth, the extensive use of antibiotics in early life, and fungi composition in the early life intestinal compartment, highlighting the mechanistic elements of fungi-epithelial function which is relevant for later risks of immune mediated chronic diseases in adulthood.
- Consider project lines on microbiota predictive biomarkers in postoperative ileus and anastomotic leakage, in adult patients.
- Get to grips with technology for label-free cell isolation: B.sight, a benchtop instrument for automated isolation of prokaryotic cells, single-cell dispensing technology
- Examine how B.sight can be used to isolate single bacteria from heterogeneous samples such as faeces or sputum for subsequent clonal cultivation or single-cell sequencing
- Explore how this technology could be an ideal tool for isolation and cultivation of potentially unknown microbial species
Microbiome equilibrium is more and more linked to different aspects of human health. Modification of the human microbiome(s) is one of the next challenge of modern medicine. There is a clear need foe new compounds allowing to tune microbiome bacterial population.
PARAGEN is a unique collection of bacteriocin (natural antimicrobial peptides) genes generated by synthetic biology. Using this collection it is possible to generate active bacteriocins and cocktails of bacteriocins.
Bacteria in their natural ecosystem are secreting bacteriocins to control the growth of microbes present in their ecological niche. For the first time the PARAGEN collection give access to a unique set of bacteriocins that could be applied to study and/or tune microbiota.
This talk will cover the disruptive approach into engineering the microbiome by delivering genetic circuit expressing CRISP-Cas or other proteins into targeted bacterial populations of the microbiome.
Keynote: The Future of Microbiome Therapeutics
The emerging science of the microbiome is still in its infancy yet it is the driving force behind a transformative scientific revolution.
- What lies ahead in the field of microbiome therapeutics will have broad implications for scientists, companies and academic institutions, our health, and perhaps for our survival.
- It is worth reflecting on where we are today, how we got here, what we have learned so far, and the limitations of our methods and of our vision.
- Case Study: Examine microbiome data from recent Amazon studies of minimally impacted Yanomami hunter-gatherers and discuss what's been learnt about our (humans) biological past that is challenging deeply held ideas about human health.
The microbial community needs validated measurements that accurately describe various properties, both quantitatively and qualitatively.
- Discover new bio-markers that may serve as disease indicators and to understand biologically-relevant properties of the human gut microbiome.
- The availability and compulsory use of the whole stool gut microbiome reference material as well as other reference materials would enable researchers to advance microbiome science through measurement assurance further and faster. While some efforts are currently moving in this direction directed in this area, no clear consensus on methods and criteria for control reagents exists.
- Examine the current state-of-the-art and novel products in the pipeline as well as suggested uses and scope of applications.
Clinical development and research are advancing at a rapid pace, but multiple questions need to be answered: