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Muthiah (Mano) Manoharan, Ph.D.

Senior Vice President of Drug Discovery at Alnylam Pharmaceuticals, Inc.


Dr. Muthiah Manoharan (“Mano”) serves as a Senior Vice President and a Distinguished Research Scientist at Alnylam Pharmaceuticals, Cambridge, Massachusetts, USA. Dr. Manoharan joined Alnylam in 2003. He was the first chemist joined Alnylam to build the chemistry group at Alnylam and pioneered the discovery of GalNAc conjugated siRNAs for RNA interference (RNAi) based human therapeutics. He was the former Executive Director of Medicinal Chemistry at Isis (Ionis) Pharmaceuticals, Inc., a leading biotechnology company focused on antisense oligonucleotide-based therapeutics where he had a12-year tenure. With a distinguished career as a chemist focused on Oligonucleotide chemistries and drug delivery chemistries , Dr. Manoharan is an author of more than 200 publications and over 300 abstracts, as well as the inventor or co-inventor on nearly 200 issued U.S. patents. Prior to Isis Pharmaceuticals, He earned his Ph.D. in chemistry at the University of North Carolina-Chapel Hill (with Professor Ernest Eliel) and conducted post-doctoral work at Yale University and the University of Maryland with Professor John A. Gerlt. He was the recipient of the M. L. Wolfrom award of the ACS Carbohydrate Chemistry Division in 2007.

Agenda Sessions