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Dharmacon revolutionized the field of RNA synthesis in 1995 with the introduction of 2’-ACE synthesis chemistry and has been a trusted provider of custom synthetic oligonucleotides for over two decades. Currently, our ISO9001:2008 certified manufacturing facility also provides quality custom oligonucleotides for research and preclinical applications. Dharmacon was an early participant in the RNA interference field with key scientific contributions to the elucidation of the biological mechanism and research tool design and established market leadership with our siRNA platform. Today, our gene modulation research tools have expanded to include CRISPR-Cas9 gene editing reagents, where our RNA synthesis platform has enabled the first arrayed whole human genome synthetic crRNA collection. Our gene editing products include predesigned genome-wide lentiviral and synthetic guide RNA reagents designed by a validated algorithm, Cas9 nucleases, and design tools & kits for homology-directed repair. We have a well-established history of supporting the global genomics research community and dedication to product innovation.