Informa Life Sciences is part of the Knowledge and Networking Division of Informa PLC
This site is operated by a business or businesses owned by Informa PLC and all copyright resides with them. Informa PLC's registered office is 5 Howick Place, London SW1P 1WG. Registered in England and Wales. Number 3099067.
Nowadays, therapeutic peptides in pharmaceutical development often contain modifications (cyclization, PEGylation, unnatural amino acids, etc.) to “improve” pharmacological properties. These improvements increase the complexity of mass spectrometry (MS)-based characterization. We show how different, tailor-made (bio)chemical and enzymatic approaches can be used to complement advanced MS-techniques. This is necessary to unveil essential information on peptide APIs, their process impurities and degradation products.