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Informa
09:00 - 09:15 15 mins
Chairperson’s Opening Remarks
  • Chairperson Bruce Morimoto - Vice President, Drug Development Operations, Alkahest, Inc
09:15 - 10:00 45 mins
Info
ANALYTICAL AND BIOANALYTICAL STRATEGIES FOR PEPTIDE DEVELOPMENT AND MANUFACTURING
Analytical Challenges In The Development Of Therapeutic Peptides: How “Improved” Peptides Can Make The Life Of A Mass Spectrometrist Difficult – And What To Do About It?
  • Thomas De Vijlder - Senior Scientist Mass Spectrometry, Janssen, Belgium

Nowadays, therapeutic peptides in pharmaceutical development often contain modifications (cyclization, PEGylation, unnatural amino acids, etc.) to “improve” pharmacological properties. These improvements increase the complexity of mass spectrometry (MS)-based characterization. We show how different, tailor-made (bio)chemical and enzymatic approaches can be used to complement advanced MS-techniques. This is necessary to unveil essential information on peptide APIs, their process impurities and degradation products.

10:00 - 10:30 30 mins
ANALYTICAL AND BIOANALYTICAL STRATEGIES FOR PEPTIDE DEVELOPMENT AND MANUFACTURING
Morning Coffee & Networking
10:30 - 11:15 45 mins
Info
ANALYTICAL AND BIOANALYTICAL STRATEGIES FOR PEPTIDE DEVELOPMENT AND MANUFACTURING
Towards Solving the Puzzle of Peptide Higher Order Structure (HOS)
  • Dr. Viv Lindo - Associate Director, MedImmune
  • Peptide critical quality attributes
  • Analytical testing to determine peptide HOS
  • Peptide isomerisation
  • Peptide self-association
11:15 - 12:00 45 mins
ANALYTICAL AND BIOANALYTICAL STRATEGIES FOR PEPTIDE DEVELOPMENT AND MANUFACTURING
Bioanalytical Analysis of Peptides
  • Bruce Morimoto - Vice President, Drug Development Operations, Alkahest, Inc
12:00 - 13:00 60 mins
ANALYTICAL AND BIOANALYTICAL STRATEGIES FOR PEPTIDE DEVELOPMENT AND MANUFACTURING
Lunch
13:00 - 13:45 45 mins
ANALYTICAL AND BIOANALYTICAL STRATEGIES FOR PEPTIDE DEVELOPMENT AND MANUFACTURING
Practical approach of Systematic Columns Screening with Waters Acquity H-Class system
  • Jerome Pretre - Senior Analytical Chemist, Almac Group
13:45 - 14:30 45 mins
ANALYTICAL AND BIOANALYTICAL STRATEGIES FOR PEPTIDE DEVELOPMENT AND MANUFACTURING
Group Discussion: Analytical and Bioanalytical Strategies for Peptide Development and Manufacturing
  • Thomas De Vijlder - Senior Scientist Mass Spectrometry, Janssen, Belgium
  • Dr. Viv Lindo - Associate Director, MedImmune
  • Jerome Pretre - Senior Analytical Chemist, Almac Group
14:30 - 14:35 5 mins
End of Day 4 and EuroPeptides 2018