Today’s Pharmaceutical companies are faced with the challenge of bringing drugs to the market faster while also reducing drug development costs by maximizing efficiencies. In order for Pharmaceutical companies to continue evolving into more effective entities in the digital world, software synchronization is essential. This has encouraged collaboration amongst software vendors to offer Sponsors new and innovative solutions that will assist them with this process. However, many Sponsors are still unaware of what is entailed in the integration of clinical systems such as electronic Trial Master Files (eTMF), Clinical Trail Management Systems (CTMS), and Electronic Data Capture (EDC). In order to offer some insight into this process, a case study was prepared to highlight several software vendors with working integrations. They were evaluated by comparing the cost, time, and benefits associated with integrating document management systems, CTMS, and others.