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David O'Connell

Lecturer in Biotherapeutics, School of Biomolecular & Biomedical Science at University College Dublin

Profile

As a member of faculty at the School of Biomolecular and Biomedical Science at University College Dublin I have developed and now direct the MSc in Biotherapeutics and MSc in Biotherapeutics  & Business taught masters programmes and I teach undergraduate biochemistry and pharmacology. My funded research has led to the development of a spin out company to commercialise a novel patented affinity technology.My research laboratory concentrates on the development and application of new methodologies in the study of protein:protein interactions with a particular focus on calcium binding proteins signalling inside the cell, to GPCR membrane receptors receiving signals from outside the cell. My lab employs a range of biophysical and proteomics-based approaches to identify interactions between signalling proteins and their target proteins to resolve functional networks. In applied research I am developing novel technologies centering on patented EF hand based affinity tags to purify and stabilize proteins from expression milieu and development of new approaches for their biophysical characterisation, chiefly high throughput Surface Plasmon Resonance (HTSPR) and single step purification methodologies for improved production of biotherapeutics. We are commercialising a novel affinity resin for bioprocessing applications.

Agenda Sessions