Andrew Zydney, Ph.D. - Distinguished Professor and Department Head, Chemical Engineering, The Pennsylvania State University
WORKING GROUP - will continue through break
The trouble with scale – why is it so difficult to scale up or scale down? What are the best practices for doing so?
Department of Chemical Engineering
The Pennsylvania State University
Scale-up and scale-down are critical aspects of bioprocess development and validation, particularly in the context of virus clearance. Yet, the virus clearance performance evaluated at different scales often shows significant discrepancies. This networking session will examine some of the underlying phenomena governing the performance at different scales, including differences in feed streams (e.g., aggregate levels, storage effects), differences in equipment (e.g., flow distribution, hold-up volume), and differences in process implementation (e.g., process disruptions, transients). Efforts will be made to identify best practices that can facilitate more effective scale-up and scale-down of chromatographic, membrane, and inactivation steps for virus clearance.