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Scientific Briefing Sponsor
Schrödinger is a science and technology leader in developing chemical simulation software aimed at transforming drug discovery research. The company’s products are used by nearly all the top pharmaceutical companies worldwide. Schrödinger also engages in drug discovery collaborations utilizing its best-in-class software solutions for modeling small molecules and protein therapeutics.
Stand number
204
A Computational Framework for Predicting Protein Liabilities & Improvement of Antibody Developability
We are presenting a novel method for predicting aggregation hotspots on proteins/peptides termed "AggScore". This method is entirely structure-based and is agnostic to the presence of natural amino acids or training to amyoloidic aggregation. In addition, we introduce a machine-learning engine to address protein liabilities termed BioQSPR and showcase its versatility and applicability in retrospective and prospective examples.
