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Banting Postdoctoral Fellow at Princess Margaret Cancer Centre, University Health Network
Sarah Crome is a Banting Fellow in the laboratory of Pamela Ohashi at the Ontario Cancer Institute at Princess Margaret Cancer Centre. Her research is focused on identifying mechanism that control T cell responses and applications for immunotherapy. Her PhD was in the lab of Megan Levings at the University of British Columbia where she defined molecular, epigenetic and cellular regulatory mechanism that control human CD4+ T helper 17 cell development and function. Her postdoctoral work has identified a regulatory innate lymphoid cell (ILC) population that inhibits the activity and expansion of tumor-associated T cells and is associated with poorer clinical outcomes. Ongoing research is defining molecular interactions that control regulatory ILC function, defining mechanisms behind ILC-mediated inhibition of T cells and identifying ways to target regulatory ILCs to enhance immunotherapies.