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Research Associate, Burton Lab at The Scripps Research Institute
I am Raiees Andrabi, working as a Research Associate in the Department of Immunology and Microbiology at The Scripps Research Institute (TSRI) La Jolla, California. I received my PhD degree from Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), New Delhi India. My PhD work involved immunological and virological characterization of HIV-1 subtype C virus infections in India. During my PhD, I was awarded a pre-doctoral six-months fellowship by Fogarty center for AIDS and TB international Training and Research Program (AITRP) to participate in a training for ‘Production and characterization of anti-V3 human monoclonal antibodies’ from HIV-1 infected individuals, under the supervision of Dr. Miroslaw K Gorny and Dr. Susan Zolla Pazner at New York University. After my PhD at AIIMS, I moved to Dr. Dennis Burton Laboratory at TSRI in 2013 for my post-doctoral research training. At Scripps, my major interest has been to study the broadly neutralizing antibodies (bnAbs) that target the V2 apex quaternary epitope on HIV envelope trimer. Broadly these studies are aimed to gain molecular understanding of this region and how this information could be used to design vaccines that can focus a neutralizing immune response to this epitope. I have identified and engineered a number of Env trimer immunogens that target the germline forms of the V2 apex bnAbs and these trimers induce immunofocused cross-neutralizing Ab responses in animal models. These studies will contribute to the HIV vaccine field in general and will also improve our understanding of how such responses could be elicited in humans through vaccination.