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Rachael A. Clark, the Shing-Yiu Yip and Cecilia M. Hepp Associate Professor of Dermatology at Harvard Medical School, is a physician scientist, a human immunologist, and Director of the NIH-funded Human Skin Disease Research Center. Her research focuses on the study of human T cell responses in skin and other peripheral tissues, including T cell function in healthy skin, impaired T cell migration and responses in skin cancers, and maladaptive T cell activation in inflammatory skin diseases and cutaneous lymphomas. Her studies, driven by observations in patients and carried out on human tissues, have the goals of developing novel therapies for skin disease and advancing our understanding of human immune responses.