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Patrick Chames, PhD

Principal Investigator, Cancer Research Center of Marseille (CRCM) at INSERM


Patrick Chames obtained his phD at the "University de la Méditerranée", Marseille, France in 1997 in the field of antibody engineering. From 1997 to 2001, he worked in the laboratory of phage display pioneer Hennie R. Hoogenboom, Maastricht, NL where he isolated by phage display the first human antibody fragment specifically binding to a cancer related class I MHC complex (TCR-like antibodies). From 2001 to 2005, he worked for a french start-up company (Cellectis SA, Paris) in the field of genome engineering where he significantly contributed to the set up of an in vivo method, leading to the isolation of homing endonucleases capable of performing specific double strand break in a whole genome. In 2005 he accepted a permanent position for the French National center for research (CNRS). Since 2009, he is working for the French institute for health and medical research (INSERM, Marseille, France) in the field of therapeutic bispecific antibodies and blocking antibodies and is specialized in the use of single domain antibodies. Since 2012, he is leader of the “Antibody therapeutics and Immunotargeting team” of the Cancer Research Center of Marseille. He authored  above 90 publications including 54 peer reviewed papers, 9 book chapters and 13 patents. h-index: 31. Citations: 3871

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