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John Cambier, Ph.D.

Distinguished Professor and Chair at University of Colorado SOM

Profile

Dr. Cambier completed Masters and Ph.D. training in virology and immunology at the University of Iowa and postdoctoral training the University of Texas Southwestern Medical Center before being appointed to the faculty at Duke University in 1978. In 1983 he was recruited to the National Jewish Medical and Research Center in Denver, where he served as Head of the Division of Basic Sciences in the Department of Pediatrics. In 1999 Dr. Cambier became the first permanent chair of the Integrated Department of Immunology, a fusion of academic departments at the University of Colorado School of Medicine (CUSOM) and National Jewish Health, and in 2014 became the first permanent Chair of the merged CUSOM Department of Immunology and Microbiology.  Dr. Cambier is Distinguished Professor and Chair of the Department of Immunology and Microbiology at the University of Colorado School of Medicine, and is Editor-in-Chief of Immunological Reviews. He has published more than 300 original papers and review articles. His research is focused on intracellular signaling in cells of the immune system with particular interest in the role of inhibitory receptors and feedback regulatory circuitry in regulation of adaptive and innate immune function. Dr. Cambier is probably best known for his original characterization of structure and function of signaling components of the B cell antigen receptor, and initial description of the role of phosphotyrosine (SHP-1) and phosphoinositide (SHIP-1) phosphatases in inhibitory FcR signaling and maintenance of B cell anergy. More recent studies have focused on the molecular signaling pathways that normally silence autoreactive B cells, and how they are defeated in development of autoimmunity, as well as strategies to harness these pathways for therapeutic purposes.

Dr. Cambier is a Distinguished Professor and the Chair of the Department of Immunology and Microbiology at the University of Colorado School of Medicine, and is Editor-in-Chief of Immunological Reviews. He has published more than 300 papers/chapters/books and is an expert in the cell signaling and the role of B lymphocytes in development of autoimmune diseases, particularly T1D and Lupus.

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