Regulation of Autoantibody Activity by the IL-23–TH17 Axis and Its Impact on Autoimmune Disease
Our recent data show that the IL-23–TH17 axis controls the intrinsic inflammatory activity of autoantibodies and thereby triggers the clinical onset of autoimmune arthritis in mice and humans suffering from rheumatoid arthritis. TH17 cells regulate expression of sialyltransferases in newly differentiating antibody-producing cells and determine the glycosylation profile and activity of immunoglobulin G (IgG) that is produced by the consecutively emerging plasma cells.
Gerhard Krönke, M.D. -
Professor of Translational Immunology, Department of Internal Medicine 3,
University of Erlangen-Nuremberg