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Research Associate at University College London Cancer Institute
Dr. Arce Vargas obtained his medical degree from the Universidad de Costa Rica and then completed post-graduate training in Surgical Oncology in San Jose, Costa Rica. Following his interest in cancer research, Dr. Arce Vargas moved to London and completed a PhD in Immunology with Prof. Mary Collins in University College London, where he worked on genetic modification of dendritic cells for tumour immunotherapy. Since 2011, he has been working in the Cancer Immunotherapy Unit of the UCL Cancer Institute with Sergio Quezada and Karl Peggs. His work has focused on engineering of antibodies targeting immune checkpoints for tumour immunotherapy. With Drs. Quezada and Peggs, he has shown that the mechanism of action of immune modulatory antibodies goes beyond the blocking or engaging of co-inhibitory and co-stimulatory receptors, involving a more complex interaction with Fc gamma receptors and other cellular networks in the tumor microenvironment.