Investigating the Basis for Efficacy and Resistance to Tumor Immunotherapy
The reasons why some tumors respond to immunotherapy while others resist are incompletely understood. Applying mass cytometry and novel informatics tools to investigate these questions in mice, we discovered that effective immunotherapy requires a coordinated system-wide immune response involving multiple immune cell types. The results also reveal a critical role for CD4 T effector-memory cells and demonstrate how one mechanism of resistance can develop. The methods we developed for these studies can be used to analyze the effects of any disease or intervention on the immune system.