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VP, Antibody Discovery Services at Ligand Pharmaceuticals
Bill received his graduate training in immunology at UCSF and has held research director positions in biotech and pharma companies. His primary focus has been the invention, development, and use of new technology for antibody discovery. In 2008 Bill co-founded Crystal Bioscience and became its CSO with the goal of creating the most diverse and effective antibody repertoires possible from wild-type and transgenic animal systems.
HuMab chickens: The Next Generation Antibody Discovery Platform
Transgenic rodents producing human sequence antibodies are widely accepted as a reliable source of therapeutic candidates. However, their repertoires are limited by their evolutionary similarity to humans. Crystal Bioscience has expanded the repertoire of transgenic animals by engineering HuMab chickens producing fully human sequence, high affinity mAbs. In addition to revealing novel epitopes and, therefore novel IP, the Crystal Platform yields mAbs recognizing murine orthologs of human antigens that facilitate pre-clinical studies.