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Professor, Science Faculty at Utrecht University
Albert J.R. Heck is professor at the Science Faculty of Utrecht University, The Netherlands. Heck’s group focuses on the development and applications of advanced mass spectrometry based technologies and instruments for proteomics and structural biology. Enabling proteomics technologies he contributed to include the efficient enrichment of phosphopeptides, novel proteases for digestions and novel fragmentation methods for (glyco)protein and peptide sequencing. Heck’s proteomics research focuses for a large part on stem cells and immunology. Complementary to the proteomics efforts, the group of Albert Heck is also known for its specific expertise in the mass spectrometric analysis of intact proteins and protein complexes. He developed therefore dedicated instruments, with most recently a new modified Orbitrap with extended mass range that can be used for native mass spectrometry and top-down (glyco)proteomics. Research in mass spectrometry based structural biology focuses on virus assembly, therapeutic antibodies, transcription complexes, circadian rhythms and CRISPR related protein assemblies.