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John McCafferty was one of the founders of Cambridge Antibody Technology (CAT, now Medimmune) in 1990 and published the first paper/patent describing antibody phage display. After 12 years at CAT, John set up groups at the Sanger Institute and then The University of Cambridge developing and utilising methods for protein generation and recombinant antibody isolation for research and therapeutic applications. In 2012 John formed IONTAS, a small innovative biotechnology company using phage display to develop novel antibody therapeutics. IONTAS have also developed a novel technology allowing discovery of IgG formatted antibodies directly from very large mammalian display libraries. In addition IONTAS have developed a novel antibody fusion format (KnotBodies) which facilitates the generation of ion channel blocking drug molecules.